Hybrid central giant cell granuloma and central odontogenic fibromalike lesion of the mandible. Peripheral giant cell granuloma or the socalled giant cell epulis is the most common oral giant cell lesion. Giant cell fibroma most commonly affects the age group 1030 years. Combined central odontogenic fibroma and giant cell granulomalike lesion of the mandible.
Ossifying fibroma of of the jaw is a benign neoplasm that consists of variable amounts of mineralized material embedded in a fibrous stroma. Also called giant cell epulis, giant cell reparative granuloma, osteoclastoma, myeloid epulis epidemiology. Hybrid central giant cell granuloma and central odontogenic. The neoplastic status of the central giant cell granuloma of the jaws remains an unsolved contro versy in anatomic pathology. Central odontogenic fibroma is a benign neoplasm of mesenchymal origin that makes up less than 5% of odontogenic tumors. Central giant cell granuloma cgcg is a locally destructive but benign lesion of. Central giant cell granuloma associated with central. We subsequently reached the final diagnosis of a hybrid lesion demonstrating central giant cell granuloma in occurrence with juvenile trabecular ossifying fibroma. Central giant cell granuloma and fibrous dysplasia. Giant cell fibroma is a small usually less than 5mm diameter firm lump in the mouth, often with a folded or pebbly surface. The lesion was excised and the area thoroughly curetted. Clinical, imaging and histopathological features indicate a hybrid lesion of cgcg. Both are included in clinical differential diagnoses of common benign and reactive gingival epulides in humans.
Central odontogenic fibroma with giant cell granulomalike lesion. Giant cell fibroma a case report international journal. Request pdf synchronous central giant cell granuloma and ossifying fibroma of the mandible central giant cell granuloma cgcg is a benign lesion of the jaws. Central giant cell granuloma cgcg is a locally destructive but. The most common oral locations are on the gingiva of the mandible, tongue, and palate.
Apr 17, 2015 today i have no problem, i even had an emotional time over the weekend where i did eat a little too much but it didnt affect me at all. Epithelium rich type central odontogenic fibroma in maxilla. Pdf central odontogenic fibroma combined with central. It is uncommon, accounting for less than 5% of odontogenic tumors. Peripheral giant cell granuloma central giant cell granuloma aneurysmal bone. The patient, a 19yearold female, presented with a domeshaped lesion of normal mucosal color on the attac hed gingiva apical to tooth number 11. Different studies reported high variability in the incidence rate as being between 3 and 23% of all odontogenic tumors 2,3. Giant cell granuloma an overview sciencedirect topics. The peripheral ossifying fibroma pof is a reactive gingival overgrowth occurring frequently in the anterior maxilla. It belongs to the broad category of fibrous hyperplastic lesions of the oral cavity.
A hybrid giant cell granuloma and fibroosseous lesion of the. Treatment since there were no true pockets present with the same region, excision of the lesion by means of gingivectomy was performed. Synchronous central giant cell granuloma and ossifying. For many years there was considerable confusion concerning the criteria by which the lesion should be diagnosed and as a result, a verity of different conditions were being reported as odontogenic fibroma of. It belongs to the broad category of fibrous hyperplastic lesions of the oral. Clinically it usually manifests as a small, may have be sessilepeduncalate lesion.
While the coexistence of two of them is reported in the literature, existence of all three conditions in one patient is an extremely rare entity. It is painless, often has lobules nodules on its surface. It most commonly occurs on the gums, more commonly on the lower than upper. Eversole and rovin compared 279 fibrous hyperplastic lesions that were categorized into four types, namely pyogenic granuloma, peripheral gingival fibroma, peripheral giant cell granuloma, and peripheral ossifying fibroma. Socalled hybrid central odontogenic fibromacentral giant cell lesion of the jaws. I did not binge eat or get worried i just let the food digest, had a good rest and was back to myself the next day, just what normal people experience.
Dec 01, 2015 odontogenic fibroma of, a rare odontogenic tumor of mesodermal origin, has been thought to originate from either dental follicle, periodontal ligament, or dental papilla 1. Peripheral giant cell granuloma and peripheral ossifying fibroma in children. Giant cell fibromas gcf of the oral cavity are found predominantly in caucasians and rarely in other races. Case report open access a peripheral giant cell granuloma. Case report giant cell tumor of the maxilla in an 8 year. Case report giant cell tumor of the maxilla in an 8 year old boy.
Giant cell fibroma gcf is a rare case with unique histopathology. It originates in the cells of the periodontal ligament and is more common in children and young adults. Giantcell fibroma is a type of fibroma not associated with trauma or irritation. Introduction central odontogenic fibroma cof is a benign neoplasm of mesenchymal origin.
What are the clinical features of giant cell fibroma. Central giantcell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. Prophylaxis was performed in relation to the involved adjacent teeth. These cells are easily observed in the peripheral areas of the lesion, while the more central areas contain typical fusiform fibroblasts. Giant cell reparative granuloma gcrg is an uncommon and nonneoplastic reactive tumor that involves the maxilla and mandible in the region of the head and neck. Giant cell fibroma is a type of fibroma not associated with trauma or irritation. Oral surg oral med oral pathol oral radiol endod, 2007. There are also reports of cgcl with ameloblastoma, and several nonodontogenic fibroosseous lesions 17,18.
If the inline pdf is not rendering correctly, you can. Central odontogenic fibroma combined with central giant cell. Central giant cell granuloma associated with central ossifying fibroma of the jaws. It normally presents as a soft tissue purplishred nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. It was jaffe who first introduced the term central giant cell reparative granuloma to distinguish this lesion from the giant cell tumor of long bones. Central giant cell granuloma and fibrous dysplasia occurring in the.
A peripheral giant cell granuloma with extensive osseous. Socalled hybrid central odontogenic fibroma central giant cell lesion of the jaws. In the current article a case of peripheral ossifying fibroma pof in the anterior maxillary gingiva is highlighted, which histologically showed cellular, fibrous. Odontogenic fibroma of, a rare odontogenic tumor of mesodermal origin, has been thought to originate from either dental follicle, periodontal ligament, or dental papilla 1. It makes up less than 5% of odontogenic tumors and is more commonly seen in females. In contrast to an irritation fibroma, a giant cell fibroma has thin, elongated rete ridges. Odell ew, lombardi t, barrett aw, morgan pr, speight pm.
Central giant cell granuloma and fibrous dysplasia occurring in the same jaw is rarely reported in the literatures. Pdf giant cell fibromas gcf of the oral cavity are found predominantly in caucasians and rarely in other races. Finally, kessler presented a case diagnosed as central odontogenic fibroma with central giant cell granuloma in the 2006 meeting of the western society of teachers of oral pathology bringing the. The true nature of these lesions is unknown but, as they are invariably destructive, the term reparative giant cell granuloma would. Histological findings showed a benign giantcell fibroma.
Lesions consisting of an association of characteristics from different pathologies have been reported in the literature. Giant cell fibroma gcf is an asymptomatic nodular mass lesion, sessile or pediculated, generally with a diameter equal. Hybrid central giant cell granuloma and central odontogenic fibromalike lesions of the jaws. Pathology outlines peripheral giant cell granuloma. A giant cell fibroma, a type of fibrous hyperplasia, was discovered during a preventive patient visit in the dental hygiene clinic at a midwestern university. Hyperparathyroidism cherubism histiocytosis neoplastic. There is a variation of this lesion that includes a zone of giant cells. Central odontogenic fibroma, central giant cell granuloma, hybrid central odontogenic fibroma with giant cell granulomalike lesion, world health organization introduction central odontogenic fibroma cof is a rare odontogenic tumor known to occur in patients in the age range of 480 years mean age, 40 years. An analysis of peripheral giant cell granuloma associated with dental implant treatment. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings.
Peripheral giant cell granuloma central giant cell granuloma aneurysmal bone cyst traumatic bone cyst metabolic. Cgcg is described as a benign lesion affecting the mandible and maxilla that consists of a massive fibrohistiocytic prolife ration. Odontogenic cysts, odontogenic tumors, fibroosseous, and. Dec, 2018 how can oral giant cell fibroma be prevented. Pdf central odontogenic fibroma combined with central giant. Central giantcell granuloma cgcg is a localised benign condition of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Outcomesresolutions the prognosis of oral giant cell fibroma is excellent on its complete surgical removal. Giant cell fibroma gcf is considered a distinct variant among the fibrotic soft tissue lesions. Hybrid central odontogenic fibroma with giant cell granuloma. Apr 14, 2008 lesions consisting of an association of characteristics from different pathologies have been reported in the literature. Central odontogenic fibroma combined with central giant cell lesion. Hybrid central odontogenic fibromacentral giant cell.
Peripheral giant cell granuloma and peripheral ossifying fibroma are clinicopathologically distinct gingival lesions. In an even lower percentage of cases, there is a variant consisting of an area of central giant cell granuloma cgcg. Central giant cell granuloma is considered widely to be nonneo. Hybrid central odontogenic fibroma with giant cell. The histologic, radiographic, and clinical presentation suggests a hybrid lesion with features of both central giant cell granuloma and cementoosseous dysplasia. Central giant cell granuloma cgcg is a benign lesion of the jaws. May 31, 2018 these cells are easily observed in the peripheral areas of the lesion, while the more central areas contain typical fusiform fibroblasts. We present a case of a 21yearold woman who had a asymptomatic nodular injury located on the lingual gums at the height of the second upper left premolar. Central odontogenic fibroma combined with central giant. Central giant cell granuloma in 1953 jaffe first described cgcg as giant cell reparative granuloma. It may be on a small stalk pedunculated or domeshaped like a limpet. Giant cell fibromas gcfs are a separate category under fibromas, that was first discovered by weathers and callihan in 1974. The central giant cell granuloma is an uncommon lesion only seen in the toothbearing regions of the jaws, most commonly in the mandible and typically in the second and third decades. A hybrid giant cell granuloma and fibroosseous lesion of the mandible.
The giant cell fibroma is a localized reactive proliferation of fibrous tissue, much like the irritation fibroma. Cgcg is described as a benign lesion affecting the mandible and maxilla that consists of massive fibrohistocytic proliferation with numerous heavily haemosidrin laden multinucleated giant cells. Central odontogenic fibroma associated with central giant cell granuloma cgcg in some cases, the cof and cgcg histologic components were not intimately admixed. Cooccurrence of calcifying odontogenic cyst, aggressive. It is a localized reactive proliferation of fibrous connective tissue. Reactive lesions and neoplasms comprise the spectrum of local. It is often impossible to make a clinical distinction between the two entities, thereby making definitive diagnosis dependent on histopathologic features. Complete excision of the lesion was performed, and the anatomopathological examination showed features of both cgcg and a fibroosseous lesion. The surface epithelium is often corrugated and atrophic. Case report fibrous epulis misdiagnosed for combined periodonticendodontic lesion khzam 1n, shah mansouri r2, poli a3, bakr mm4 abstract fibrous epulis or peripheral ossifying fibroma is a reactive nonneoplastic condition that affects the gingiva as a result of chronic irritation. A hybrid giant cell granuloma and fibroosseous lesion of. It is rare in the nasal cavity, and it might be misdiagnosed. Case report fibrous epulis misdiagnosed for combined.
Peripheral giant cell granuloma pubmed central pmc. Pdf benign gingival overgrowths are not uncommon in the oral cavity. It is believed to be the oral equivalent of fibrous papule of the noseface who gets giant cell fibroma. It can occur at any age and on a mucous membrane surface. In most cases, the lesion presents as a painless, slowgrowing swelling of the jaws. The first case, a cgcg arising within a preexisting ossifying fibroma, was treated with a left partial maxillectomy.
Hybrid central giant cell granuloma and central odontogenic fibroma like lesions of the jaws. Unusual mandibular lesion of central odontogenic fibroma. Central odontogenic fibroma cof is an uncommon intraosseous neoplasm of the gnathic bones which is composed of fibrous connective tissue, with or without calcifications, and variable amounts of inactive odontogenic epithelium. Central odontogenic fibroma, central giant cell lesion, ck19, cd68. Identification of a giant cell fibroma sherri m lukes, joleen kuhnert and mark a mangels sherri lukes, rdh, ms, is an assistant pr ofessor in the dental hygiene pr ogram at southern illinois univer sity at carbondale, where. Hybrid lesions involving central giant cell granulomas cgcg and fibroosseous components are very rare in the jaws, with only six cases reported in the literature. Epithelium rich type central odontogenic fibroma in. Usually women, 30s to 50s, although may involve children or elderly patients without teeth. Oral surg oral med oral pathol oral radiol endod 2007. It is twice as common in females and is more likely to occur before age 30. It is distinguishable from pyogenic granuloma and peripheral ossifying fibroma only on the basis of its unique histomorphology, which is the same as central giant cell granuloma 8, 9.
The peripheral giant cell granuloma, also known as giant cell epulis, pgcl or giant cell hyperplasia, is the most common giant cell lesion in the. Peripheral and central giant cell granulomas of the jaws. We subsequently reached the final diagnosis of a hybrid lesion demonstrating central giant cell granuloma in occurrence with. Calcifying odontogenic cyst coc, central odontogenic fibroma cof and aggressive central giant cell granuloma cgcg are rare pathologic diseases affecting the jaws. It usually occurs in young people without any gender predilection. The referring doctor had suggested a diagnosis of eruption cyst. Interrelationship between pyogenic granuloma and peripheral. This peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl.
Unusual mandibular lesion of central odontogenic fibroma combined with mandibular giant cell central granuloma mx ther the maxilla or the mandible, posterior or anterior zone of the mouth. Like pyogenic granuloma and peripheral ossifying fibroma, peripheral giant cell granuloma may represent an unusual response to tissue injury. A case report and update of giant cell fibroma dergipark. We hereby report a case of a rare hybrid lesion comprising cgcg and jtof. Hybrid central odontogenic fibromacentral giant cell lesion. The clinical, radiographical, surgical and histopathological features are discussed.
1409 579 1037 568 995 216 885 687 1043 914 329 477 1185 517 1394 1182 916 294 442 896 695 671 425 683 1252 349 1316 8 1058 990 761 1174 206 213 60 309 727 560 620 1089 548 1350 535 157 476